What question did this study set out to answer?

To determine the relative contributions of circulating monocyte influx and local cellular proliferation in maintaining the alveolar macrophage population in normal rats.

January 1, 1987

Maintenance of the normal rat alveolar macrophage cell population. The roles of monocyte influx and alveolar macrophage proliferation in situ.

View Full Paper

Ask AI

Bookmark

Authors

JSJudd E. ShellitoLouisiana State University CEC. EsparzaUniversidad de Granada CACharles ArmstrongBayer (United States)

Discussion

Member takes

Implication

In vivo animal study reveals alveolar macrophage proliferation sustains pulmonary immune cells in normal rats, indicating minimal contribution from direct monocyte influx.

Key Points

To determine the relative contributions of circulating monocyte influx and local cellular proliferation in maintaining the alveolar macrophage population in normal rats.
Infused rats continuously with tritiated thymidine for 7 days to radiolabel blood monocytes, evaluating lavaged alveolar macrophages using autoradiography.
Administered colchicine in vivo to normal unlabeled rats to arrest dividing cells and quantify daily mitotic rates of lavaged alveolar macrophages.
Continuous tritiated thymidine infusion produced heavily labeled blood monocytes, but no heavily labeled cells appeared among lavaged alveolar macrophages by cohort analysis.
Colchicine arrest demonstrated active cell division among lavaged alveolar macrophages, with calculations indicating 1.83% of cells enter mitosis each day.

Cite This Study

Shellito et al. (1987) studied this question.

synapsesocial.com/papers/6a91588d85dcbcf0c3dd43b1 https://doi.org/10.1164/arrd.1987.135.1.78

View Full Paper

Ask AI

Bookmark

Implication

In vivo animal study reveals alveolar macrophage proliferation sustains pulmonary immune cells in normal rats, indicating minimal contribution from direct monocyte influx.

Maintenance of the normal rat alveolar macrophage cell population. The roles of monocyte influx and alveolar macrophage proliferation in situ.

Discussion

Member takes

Implication

Key Points

Cite This Study

Maintenance of the normal rat alveolar macrophage cell population. The roles of monocyte influx and alveolar macrophage proliferation in situ.

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider