The Diagnosis and Treatment of Deep-Vein Thrombosis

In this issue of the Journal, two important aspects of venous thromboembolism are discussed. In one, a joint Canadian-Dutch study, two noninvasive methods of diagnosing deep-vein thrombosis in symptomatic outpatients are compared1. In the other, a Canadian-American multicenter trial, two antithrombotic methods are explored in orthopedic patients with a very high risk of thrombosis2. This editorial discusses the diagnosis and prevention of venous thromboembolism, a disorder that continues to exact a considerable toll in morbidity and mortality.Outpatients with clinical signs and symptoms suggestive of deep-vein thrombosis of the legs present a diagnostic problem, because in more than . . .