What question did this study set out to answer?

To assess the clinical safety of substituting invasive venography with combined impedance plethysmography and 125I-fibrinogen leg scanning to guide anticoagulation therapy in suspected venous thrombosis.

January 1, 1981Annals of Internal Medicine

Replacement of Venography in Suspected Venous Thrombosis by Impedance Plethysmography and 125I-Fibrinogen Leg Scanning

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Authors

RHRussell D. HullVascular Medicine

Discussion

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Implication

Prospective study demonstrates safe withholding of anticoagulants after negative noninvasive tests in suspected venous thrombosis, indicating these methods safely replace venography.

Key Points

To assess the clinical safety of substituting invasive venography with combined impedance plethysmography and 125I-fibrinogen leg scanning to guide anticoagulation therapy in suspected venous thrombosis.
Conducted a prospective study of 322 symptomatic patients evaluated for clinically suspected venous thrombosis.
All patients underwent venography alongside noninvasive impedance plethysmography and 125I-fibrinogen leg scanning.
Anticoagulant therapy was withheld if noninvasive test findings were negative regardless of venography results, and patients were followed for 3 months.
In 163 patients with negative noninvasive tests, zero patients died or developed clinical pulmonary embolism during the 3-month follow-up period.
Two patients developed postvenographic venous thrombosis that was subsequently confirmed by repeat noninvasive testing.
Positive predictive values supported initiating treatment based on positive noninvasive results in patients without conditions predisposing to false positives.

Cite This Study

Russell D. Hull (1981) studied this question.

synapsesocial.com/papers/6a8381e052df268f62f70869 https://doi.org/10.7326/0003-4819-94-1-12

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Implication

Prospective study demonstrates safe withholding of anticoagulants after negative noninvasive tests in suspected venous thrombosis, indicating these methods safely replace venography.

Replacement of Venography in Suspected Venous Thrombosis by Impedance Plethysmography and 125I-Fibrinogen Leg Scanning

Discussion

Member takes

Implication

Key Points

Cite This Study

Replacement of Venography in Suspected Venous Thrombosis by Impedance Plethysmography and 125I-Fibrinogen Leg Scanning

Discussion

Member takes

Implication

Key Points

Cite This Study

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