Why the study?
Does neostigmine induce hyperperistalsis and affect colonic anastomosis in a canine model?
Does neostigmine induce hyperperistalsis and affect colonic anastomosis in a canine model?
Neostigmine induces severe colonic spasm and pressure increases in dogs that are not prevented by standard doses of atropine, though it does not disrupt colonic anastomoses.
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Neostigmine provokes atropine-resistant colonic spasm in canines; leaves open relevance to human anastomotic safety and postoperative ileus management.
Neostigmine methylsulfate, a muscarinic drug, is frequently employed to reverse the paralytic effect of curare at the conclusion of surgical procedures. The experiments reported document the potent muscarinic effect of neostigmine on the large bowel, causing intraluminal colonic pressure to rise 15 times above base line. This is accompanied by severe spasm, associated with foreshortening and hypersegmentation of the bowel. The prior administration of atropine sulfate, an antimuscarinic drug, in the dose customarily employed during anesthesia, does not ameliorate or abolish the muscarinic effect of neostigmine on the canine colon. The muscarinic effects of neostigmine did not result in the disruption of an anastomosis fashioned in the canine colon.
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Albert E. Yellin (1973) studied this question.
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