Key result
BISpro and BIS both correlated well with sedation levels during propofol anaesthesia, but BISpro demonstrated a significantly lower prediction probability for OAA/S scores compared to BIS (0.879 vs 0.943, p<0.01) and poor agreement.
Why the study?
The study was conducted to compare the accuracy, correlation, and agreement between the bispectral index (BIS) and BISpro during propofol anaesthesia.
Does BISpro correlate and agree with BIS for monitoring the depth of propofol anaesthesia in female patients undergoing hysteroscopic surgery?
Observational (n=30)
No
Does BISpro correlate and agree with BIS for monitoring the depth of propofol anaesthesia in female patients undergoing hysteroscopic surgery?
Absolute Event Rate: 0.879% vs 0.943%
p-value: p=<0.01
BISpro correlates well with BIS and clinical sedation scores during propofol anaesthesia but demonstrates poor absolute agreement with BIS and lower accuracy in distinguishing light sedation states.
BISpro correlates closely with BIS during propofol sedation; leaves open routine interchangeability pending larger validation.
OBJECTIVE: To compare the accuracy, correlation and agreement between the bispectral index (BIS) and BISpro during propofol anaesthesia. METHODS: The BIS, BISpro, heart rate, target-concentration of propofol and Observer's Assessment of Alertness and Sedation (OAA/S) score were recorded every 30 s in female patients scheduled for hysteroscopic surgery. Propofol anaesthesia was induced by an initial target-controlled concentration (1.0 μg/ml) followed by a stepwise increase (0.5 μg/ml) until the patient was unresponsive. Spearman's correlation coefficient and prediction probability were calculated for the association between sedation levels and the above parameters. The ability of investigated parameters to distinguish between OAA/S scores was analysed. Bland-Altman analysis was used to compare the agreement between BIS and BISpro. The BIS and BISpro cut-off values for lost response were also determined. RESULTS: Out of 30 patients in total, a high correlation was found between BIS and BISpro, and both correlated well with OAA/S score. Only BIS was able to distinguish all investigated OAA/S states accurately, but the ability to predict OAA/S score 5 to loss of response was comparable between BIS and BISpro. The calculated cut-off values were 68 for BIS and 70 for BISpro. CONCLUSION: : Chinese Clinical Trial Registry (URL: www.chictr.org.cn): ChiCTR1900024037 (retrospectively registered).
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Li et al. (2021) conducted an observational in Propofol anaesthesia for hysteroscopic surgery (n=30). BISpro monitoring vs. BIS monitoring was evaluated on Prediction probability (PK) for Observer's Assessment of Alertness and Sedation (OAA/S) score (p=<0.01). BISpro and BIS both correlated well with sedation levels during propofol anaesthesia, but BISpro demonstrated a significantly lower prediction probability for OAA/S scores compared to BIS (0.879 vs 0.943, p<0.01) and poor agreement.
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