Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.
Population
32 monozygotic and 47 dizygotic adult twin pairs of the same sex (n=158 individuals)
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports genetic research into IGF variation; should not yet inform clinical measurement or risk assessment.
Structured PICO
P
Population
32 monozygotic and 47 dizygotic adult twin pairs of the same sex (n=158 individuals)
O
Outcome
Intrapair correlation and heritability of circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3surrogate
There is a substantial genetic contribution to the interindividual variation in circulating levels of IGF-I, IGF-II, and IGFBP-3 in adults, but not for IGFBP-1.
Cite This Study
Harrela et al. (1996) studied this question.