Key result
Late presentation (>6 hours) for possible acute coronary syndrome was associated with a higher 1-year rate of adverse cardiac outcomes compared to early presentation (HR 1.57; 95% CI 1.07-2.31).
Why the study?
Does delayed presentation to the emergency department with symptoms of possible ACS increase the risk of adverse cardiovascular outcomes at 1 year?
Cohort (n=2,515)
Yes
Does delayed presentation to the emergency department with symptoms of possible ACS increase the risk of adverse cardiovascular outcomes at 1 year?
Hazard Ratio: 1.57 (95% CI 1.07–2.31)
Late presentation (>6 hours) to the emergency department for suspected ACS is independently associated with a significantly higher risk of 1-year adverse cardiac outcomes compared to early presentation.
No takes yet. Share an insight, caveat, or question.
Delayed presentation signals higher 1-year risk in suspected ACS but should not yet change practice; leaves open causal mechanisms and intervention targets.
Cullen et al. (2016) conducted a cohort in Suspected acute coronary syndrome (ACS) (n=2,515). Late presentation (>6 hours post-symptom onset) vs. Early presentation was evaluated on Composite of death, acute myocardial infarction, unstable angina pectoris treated with revascularisation or readmission with heart failure occurring after discharge but within 12 months (HR 1.57, 95% CI 1.07 to 2.31). Late presentation (>6 hours) for possible acute coronary syndrome was associated with a higher 1-year rate of adverse cardiac outcomes compared to early presentation (HR 1.57; 95% CI 1.07-2.31).
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