Key result
The AGCT haplotype of EDN1 and NOS3 genes was associated with a twofold increased risk of developing stable coronary artery disease.
Why the study?
The study was conducted to evaluate the role of polymorphisms in cell adhesion genes (SELE, SELP, SELPLG), EDN1, and NOS3 in the individual risk of coronary artery disease.
Are polymorphisms in SELE, SELP, SELPLG, EDN1, and NOS3 genes associated with the risk of developing stable ischemic heart disease?
Case-Control (n=560)
Are polymorphisms in SELE, SELP, SELPLG, EDN1, and NOS3 genes associated with the risk of developing stable ischemic heart disease?
Specific polymorphisms and haplotypes in atherogenesis-related genes (EDN1, NOS3, SELE) are significantly associated with the risk of developing stable coronary artery disease.
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Понасенко et al. (2022) conducted a case-control in Stable coronary artery disease (n=560). Polymorphisms in SELE, SELP, SELPLG, EDN1, and NOS3 genes vs. Healthy donors / absence of specific polymorphisms was evaluated on Development of coronary heart disease. The AGCT haplotype of EDN1 and NOS3 genes was associated with a twofold increased risk of developing stable coronary artery disease.
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