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The uptake and distribution of 5-fluorouracil-2-14C (FU) and its metabolites were determined in normal brain and an intracerebral glioma of C57BL/6 mice during maintenance of a steady-state concentration of FU in plasma. After 1 hour, FU reached a concentration in tumor approximately 11 times that in normal brain. 5-Fluoro-2′-deoxyuridine-5′-monophesphate (FdUMP), believed to be the chemotherapeutically active metabolite, was identified in intracerebral tumor.
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Levin et al. (1972) studied this question.
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