Key result
Masked hypertension was diagnosed in 68.6% of systematically stressed men, with systolic-diastolic and isolated diastolic phenotypes significantly associated with cardiometabolic risk factors.
Why the study?
The study was conducted to assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension.
Cross-Sectional (n=207)
Systolic-diastolic and isolated diastolic phenotypes of masked hypertension are associated with a higher burden of cardiometabolic risk factors and subclinical atherosclerosis.
May support screening stressed men for masked hypertension; leaves open whether phenotypes predict outcomes or warrant intervention.
Aim. To assess the relationship of cardiometabolic risk factors in patients with various phenotypes of masked hypertension (MH). Material and methods. The study included 207 men with a median age of 34,6 years [32,3; 36,3] being systematically stressed. All examined patients had normal clinical blood pressure (BP), and there was no history of its increase. We conducted 24-hour ambulatory blood pressure monitoring (ABPM), carotid duplex scan with determination of the intima- media thickness (IMT). The levels of total cholesterol (TC), low (LDLC) and high-density lipoprotein cholesterol (HDL-C), triglycerides (TG) were determined. Body mass index, visceral adiposity index, lipid accumulation product index and waist-to-height ratio were calculated. We performed clustering of ABPM data, calculated the odds ratio of association between cardiometabolic risk factors and certain MH phenotypes. Results. MH was diagnosed in 142 (68,6%) patients examined, divided into 3 clusters: systolic-diastolic — SDMH (50,7%), isolated systolic — ISMH (27,5%) and isolated diastolic — IDMH (21,8%). Impaired lipid metabolism, visceral adiposity, IMT increase and atherosclerotic plaques were more often recorded in patients with SDMH and IDMH. The levels of TC, LDL-C and IMT were highest in individuals with IDMH. Odds ratio analysis indicated significant associations of SDMH and IDMH phenotypes with indicators of visceral adiposity, IMT, TG, TC, LDL-C and TG/HDL-Cl. Conclusion. Clustering of ABPM data in individuals with MH and comparing related phenotypes with cardiometabolic risk factors complements their clinical and functional characteristics and can be a useful tool for improving customized prevention and therapy programs.
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Geltser et al. (2020) conducted a cross-sectional in Masked hypertension (n=207). Masked hypertension phenotypes was evaluated on Association between cardiometabolic risk factors and masked hypertension phenotypes. Masked hypertension was diagnosed in 68.6% of systematically stressed men, with systolic-diastolic and isolated diastolic phenotypes significantly associated with cardiometabolic risk factors.
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