Why the study?
What is the time course of the biologic response induced by a single intramuscular injection of rHuIFN-alpha 2a in healthy men?
What is the time course of the biologic response induced by a single intramuscular injection of rHuIFN-alpha 2a in healthy men?
The study demonstrates a parallel time course between the induction of 2-5A synthetase activity and the development of the antiviral state in peripheral blood mononuclear cells following rHuIFN-alpha 2a administration.
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May guide IFN-alpha sampling windows in research; leaves open clinical translation of PBMC antiviral kinetics.
BAROUKI et al. (1987) studied this question.
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