Design of Model for Impaired Healing of Wound Created on Oral Mucosa of Rabbits

The therapy for a refractory oral mucosal lesion is nosotropic but the effect of the therapy is insufficient. Recently, many growth factors have been developed and produced, and some of them are known not only to accelerate wound healing but also to protect cells from injury. Such growth factors are more effective when wound healing is impaired for some reasons. Therefore, it was considered that when growth factors are applied to a lesion, it is possible to obtain satisfactory effects that had been unattainable here to fore. In order to elucidate the effects of growth factors on the lesion, firstly it was attempted to establish a model for the lesion. Almost uniform, round ulcers could be created on gingiva of rabbits by chemical injury with acetic acid or NaOH. When submandibular glands of rabbits were removed or intravenous injection of CDDP and peplomycin sulfate were administered before ulcer formation, healing of the ulcers created by acetic acid took longer than that of untreated rabbits. Therefore, it was considered that the model for the lesion is useful for examining the effects of growth factors.