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August 1, 1987Neurology

Combined central and peripheral myelinopathy

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Authors

MRMichael RubinUniversity of UtahGKGeorge KarpatiMontreal Neurological Institute and HospitalSCStirling CarpenterHospital de São João

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Implication

Case series reports severe concurrent central and peripheral demyelinating disease in two men, highlighting rare overlapping myelinopathy presentations linked to multiple sclerosis.

Key Points

  • Investigate the clinical, electrophysiologic, and histopathological characteristics of severe concurrent central and peripheral demyelinating disease.
  • Evaluated clinical examinations, electrophysiologic testing, and peripheral nerve biopsy findings in two men (N=2) with manifestations of both central and peripheral demyelination.
  • Both patients demonstrated severe, chronic, clinically evident peripheral demyelinating neuropathy in combination with central nervous system demyelination.
  • Presentations indicate either a rare manifestation of multiple sclerosis involving the peripheral nervous system, a distinct combined central-peripheral myelinopathy syndrome, or a coincidence with idiopathic inflammatory-demyelinating neuropathy.

Cite This Study

Rubin et al. (1987) studied this question.

synapsesocial.com/papers/6a91677f90ff22de3cb3a79ehttps://doi.org/10.1212/wnl.37.8.1287
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characterizing Combined Central and Peripheral Demyelination—Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis2026
  2. 2Combined central and peripheral demyelination in two siblings, immune mediated or genetic?2024 · 5 citations
  3. 3Case Report: Combined central and peripheral nerve demyelination with neurofilament heavy chain antibodies2026
  4. 4B-Cell Depletion as Evidence for Shared Neuroimmune Pathways in Combined Central and Peripheral Demyelination: A Case Report and Literature Review2026
  5. 5Multiple Sclerosis in Charcot-Marie-Tooth Disease Type 1A – A Case Report and Literature Review2026