Key result
The AV TTMV/TTMDV-expanded anellome was significantly enriched in acute liver failure (31.7%) and liver transplantation (40.7%) patients vs other groups (p=4.1×10−8–3.2×10−3).
Observational (n=2,713)
p-value: p=4.1 × 10−8–3.2 × 10−3
Anellome heterogeneity, specifically the expansion of TTMV/TTMDV, is associated with severe liver disease outcomes and can be assessed via liquid biopsy.
Anellome individuality with diagnosis-linked differences may support biomarker exploration in liver disease; leaves open clinical utility without validation.
Anellovirus (AV) is a ubiquitous virus in the human population. Individuals can be infected with multiple AV genera and species to form a heterogeneous repertoire, termed the anellome. Using advanced methods, we examined the anellomes from 12 paired serum and liver samples, as well as 2701 subjects with different clinical diagnoses. Overall, anellomes are remarkably individualized, with significant among-group differences (Kruskal–Wallis test p = 6.6 × 10−162 for richness and p = 7.48 × 10−162 for Shannon entropy). High dissimilarity scores (beta diversity) were observed between patient groups, except for paired serum and liver samples. At the population level, the relative abundance of combinational AV genus Betatorquevirus (torque teno mini viruses, TTMV), and Gammatorquevirus (torque teno midi viruses, TTMDV) exhibited an exponential distribution with a low bound point at 32%. Defined by this value, the AV TTMV/TTMDV-expanded anellome was significantly enriched among patients with acute liver failure (31.7%) and liver transplantation (40.7%), compared with other patient groups (χ2 test: p = 4.1 × 10−8–3.2 × 10−3). Therefore, anellome heterogeneity may be predictive of clinical outcomes in certain diseases, such as liver disease. The consistency of anellome between paired serum and liver samples indicates that a liquid biopsy approach would be suitable for longitudinal studies to clarify the causality of the AV TTMV/TTMDV-expanded anellome in the outcomes of liver disease.
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Zhang et al. (2023) conducted an observational in Liver diseases (n=2,713). AV TTMV/TTMDV-expanded anellome vs. Other patient groups was evaluated on Enrichment of AV TTMV/TTMDV-expanded anellome (p=4.1 × 10−8–3.2 × 10−3). The AV TTMV/TTMDV-expanded anellome was significantly enriched in acute liver failure (31.7%) and liver transplantation (40.7%) patients vs other groups (p=4.1×10−8–3.2×10−3).
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