Key result
Initiation of dolutegravir treatment in two HIV patients was associated with the rapid development of severe lymphocytic myocarditis, resulting in one death and one case of severe heart failure.
Why the study?
Does dolutegravir initiation cause severe myocarditis in HIV patients?
Population
2 HIV patients with stable virological response who developed severe congestive heart failure shortly after…
Design
Case_report
Follow-up
2 to 3 weeks to symptom onset
Authors
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Warrants vigilance for myocarditis after dolutegravir initiation in HIV; leaves open causality and needs confirmation in larger cohorts.
Case Report (n=2)
No
Does dolutegravir initiation cause severe myocarditis in HIV patients?
Initiation of dolutegravir in HIV patients may be associated with the development of severe lymphocytic myocarditis.
Mahlab‐Guri et al. (2016) conducted a case report in HIV (n=2). Dolutegravir was evaluated on Development of severe myocarditis. Initiation of dolutegravir treatment in two HIV patients was associated with the rapid development of severe lymphocytic myocarditis, resulting in one death and one case of severe heart failure.
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