Key result
A two-dose intramuscular administration of thermally inactivated YK-1 rotavirus resulted in high titers of total and neutralizing antibodies in mice, which was further enhanced by Al(OH)3 adjuvant.
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May inform inactivated rotavirus vaccine development; leaves open human immunogenicity and efficacy trials.
Jiang et al. (2008) studied Rotavirus vaccine development. Thermally inactivated YK-1 rotavirus vaccine was evaluated on Total and neutralizing antibody titers in serum. A two-dose intramuscular administration of thermally inactivated YK-1 rotavirus resulted in high titers of total and neutralizing antibodies in mice, which was further enhanced by Al(OH)3 adjuvant.
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