Key result
Hypertonic saline infusion did not significantly alter plasma BNP (P=0.212) or ANP (P=0.356) levels compared to hydroxyethyl starch in post-operative coronary surgery patients.
Why the study?
Does hypertonic saline compared to hydroxyethyl starch modulate natriuretic peptide concentration in patients after coronary artery surgery?
Population
50 coronary surgery patients post-operatively
Comparison
Hypertonic saline 4 ml/kg infused within 30 min… vs Hydroxyethyl starch 4 ml/kg infused within 30…
Design
RCT, randomized, double-blinded
Follow-up
first post-operative morning
Authors
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Validates natriuretic peptides as reliable perioperative biomarkers after coronary surgery; confirms hyperosmolality does not confound their release.
RCT (n=50)
double-blinded
randomized
Does hypertonic saline compared to hydroxyethyl starch modulate natriuretic peptide concentration in patients after coronary artery surgery?
p-value: p=0.212 and 0.356
Hyperosmolality induced by hypertonic saline does not affect natriuretic peptide release, validating the use of NPs as reliable biomarkers in the peri-operative setting.
Honkonen et al. (2009) conducted an RCT in coronary surgery (n=50). Hypertonic saline (HS) vs. Hydroxyethyl starch (HES) was evaluated on Changes in plasma BNP and ANP levels (p=0.212 and 0.356). Hypertonic saline infusion did not significantly alter plasma BNP (P=0.212) or ANP (P=0.356) levels compared to hydroxyethyl starch in post-operative coronary surgery patients.
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