Key result
Metabolic syndrome was present in 59.8% of patients with peripheral arterial disease, and its score correlated with multiple vascular risk factors but not with clinical manifestation severity.
Cross-Sectional (n=388)
Metabolic syndrome is highly prevalent in patients with peripheral arterial disease and correlates with vascular risk factors, though specific factors like fasting glucose and hs-CRP are more directly associated with severe manifestations like gangrene.
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Metabolic syndrome screening may warrant consideration in PAD; confirms risk-factor links but leaves severity impact open.
The aim of the study was to estimate the prevalence of metabolic syndrome among 388 patients with peripheral arterial disease, to determine the relationship between the number of metabolic syndrome components (metabolic syndrome score) and the degree of established and some of the emerging vascular risk factors, and to estimate whether there was any relationship of metabolic syndrome score and other vascular risk factors with the severity of peripheral arterial disease clinical manifestations. Metabolic syndrome was present in 59.8% of the patients with peripheral arterial disease. All metabolic syndrome components were significantly related to metabolic syndrome score. The same was true for the body weight, body mass index, percentage of body fat, total cholesterol/high-density lipoprotein cholesterol ratio, uric acid, and percentage of patients with high-sensitivity C-reactive protein. The metabolic syndrome score was also significantly, but inversely, related to high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and smoking. The degree of peripheral arterial disease clinical manifestations was not related to metabolic syndrome score, but gangrene was significantly positively associated with increased fasting glucose, high-sensitivity C-reactive protein, and lower education.
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Maksimović et al. (2009) conducted a cross-sectional in Peripheral arterial disease (n=388). Metabolic syndrome was evaluated on Prevalence of metabolic syndrome. Metabolic syndrome was present in 59.8% of patients with peripheral arterial disease, and its score correlated with multiple vascular risk factors but not with clinical manifestation severity.
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