Why the study?
Does clonidine hydrochloride alter action potential duration in rat atrial cardiomyocytes at different developmental stages?
Does clonidine hydrochloride alter action potential duration in rat atrial cardiomyocytes at different developmental stages?
Stimulation of alpha-2 adrenergic receptors with clonidine produces age-dependent effects on atrial action potential duration in rats, shortening it in adults but prolonging it in neonates and juveniles.
Clonidine effects on rat atrial APD vary by age; hypothesis-generating for human pacing but should not change practice.
Clonidine hydrochloride, an agonist of the α2-adrenergic receptor, was tested for its effect on the parameters of the electrical activity of the atrial myocardium induced by pacing. In the experimental rat cardiomyocyte pacing model, clonidine hydrochloride caused a decrease (approximately 50% and 90%) in action potential duration in adult rats. Treatment of one- and three-week-old rats with this agonist led to an increase (around 50% and 90%) in action potential duration
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Galieva et al. (2023) studied this question. Clonidine hydrochloride was evaluated on action potential duration.
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