Key result
Methoxamine had a dual effect on the duration of repolarization of working cardiomyocytes in rat atria, increasing it with an imposed rhythm and decreasing it with an intrinsic rhythm.
Rat atrial data on methoxamine should not alter clinical α1-agonist use; leaves open rhythm-dependent repolarization mechanisms for human studies.
The effect of the α1 adrenergic receptor agonist methoxamine on the frequency of spontaneous activity and the parameters of the electrical activity of the atrial myocardium under conditions of an imposed rhythm and with a preserved sinus node in rats was studied. Methoxamine had a dual effect on the duration of repolarization of working cardiomyocytes. With an imposed rhythm, methoxamine increased the duration of the repolarization phase of the action potential, with intrinsic rhythm, it decreased the duration.
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Mansour et al. (2023) studied this question. Methoxamine was evaluated on Duration of repolarization of working cardiomyocytes. Methoxamine had a dual effect on the duration of repolarization of working cardiomyocytes in rat atria, increasing it with an imposed rhythm and decreasing it with an intrinsic rhythm.
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