September 1, 2001Hypertension
Adrenal Response to Angiotensin II in Black Hypertension
Key result
Black hypertensive patients lacked the sexual dimorphism in adrenal responsiveness to Angiotensin II seen in white patients, showing no gender difference (P=0.9) compared to whites (P=0.0001).
Why the study?
Does the adrenal response to Angiotensin II differ by race and gender in hypertensive patients?
Population
382 hypertensive patients (313 white, 69 black; 238 male, 144 female)
Comparison
Angiotensin II infusion while on a 10-mmol Na… vs Comparison between black and white hypertensive…
Design
Cross-sectional
Authors
Discussion
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Implication
May contribute to hypertension disparities in black women; hypothesis-generating and requires prospective validation before clinical consideration.
Study Design
Type
Cross-Sectional (n=382)
Structured PICO
Does the adrenal response to Angiotensin II differ by race and gender in hypertensive patients?
P
Population
382 hypertensive patients (313 white, 69 black; 37.7% female) evaluated for adrenal response to Angiotensin II infusion while on a 10-mmol Na(+) intake.
E
Exposure
Angiotensin II infusion while on a 10-mmol Na(+) intake
C
Comparator
Comparison between black and white hypertensive patients, and between genders
O
Outcome
Adrenal response (aldosterone response) to Angiotensin IIsurrogate
Main Result
p-value: p=0.9 for blacks; 0.0001 for whites
Young black women lack the protective mechanisms against blunted adrenal response to Angiotensin II seen in young white women, which may contribute to their increased prevalence of hypertension.
Cite This Study
Fisher et al. (2001) conducted a cross-sectional in Hypertension (n=382). Black race vs. White race was evaluated on Gender difference in aldosterone response to Angiotensin II (p=0.9 for blacks; 0.0001 for whites). Black hypertensive patients lacked the sexual dimorphism in adrenal responsiveness to Angiotensin II seen in white patients, showing no gender difference (P=0.9) compared to whites (P=0.0001).