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November 16, 2011BloodOpen Access

NOTCH1 mutations in CLL associated with trisomy 12

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Authors

VBVeronica BalattiThe Ohio State UniversityABArianna BottoniThe Ohio State UniversityAPAlexey PalamarchukThe Ohio State University Wexner Medical Center

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Balatti et al. (2011) studied this question.

synapsesocial.com/papers/6a917191388f32339cd2d239https://doi.org/10.1182/blood-2011-10-386144
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth2006 · 839 citations
  2. 2Unmutated Ig VH Genes Are Associated With a More Aggressive Form of Chronic Lymphocytic Leukemia1999 · 2,726 citations
  3. 3Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia2011 · 1,532 citations
  4. 4Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation2011 · 609 citations
  5. 5Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia2004 · 2,756 citations