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November 11, 1997Proceedings of the National Academy of SciencesOpen Access

The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB

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Authors

KIKenneth M. IzumiThe University of Texas System
Elliott Kieff
Elliott KieffUniversity of California, Riverside

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Izumi et al. (1997) studied this question.

synapsesocial.com/papers/6a9171ddd613fa9f3b466545https://doi.org/10.1073/pnas.94.23.12592
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epstein-Barr virus recombinant molecular genetic analysis of the LMP1 amino-terminal cytoplasmic domain reveals a probable structural role, with no component essential for primary B-lymphocyte growth transformation1994 · 71 citations
  2. 2Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP11996 · 92 citations
  3. 3Phenotypes of Epstein-Barr virus LMP1 deletion mutants indicate transmembrane and amino-terminal cytoplasmic domains necessary for effects in B-lymphoma cells1992 · 62 citations
  4. 4All three domains of the Epstein-Barr virus-encoded latent membrane protein LMP-1 are required for transformation of rat-1 fibroblasts1993 · 176 citations
  5. 5Lymphotoxin-β receptor signaling complex: Role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor κB1997 · 181 citations