Demethylation of methylated sugars can be achieved using hydrogen peroxide and ferrous iron (Fenton's reagent). The reaction is not specific and further oxidation of the sugar also occurs. The preparation of 3,4-di-O-methyl-D-mannose from the corresponding mannitol derivative is described. Mono-O-methyl derivatives of D-mannose and of D-mannitol as well as D-mannose and D-mannitol were also produced. The course of the demethylation of 2,3,4,6-tetra-O-methyl methyl α-D-glucoside by Fenton's reagent has been examined.
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Fraser‐Reid et al. (1961) studied this question.
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