Population
Normal hearts and hearts 24 hours after myocardial infarction (in vivo and in vitro preparations)
Comparison
Myocardial infarction and beta-adrenergic blockade vs Normal hearts and pre-beta-blockade state
Design
Preclinical
Follow-up
24 hours (post-MI)
Authors
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Pacemaker shift to infarct zone post-MI is hypothesis-generating for ventricular arrhythmias; requires human studies before clinical translation.
The study demonstrates that dominant ventricular pacemakers are normally located in the proximal conduction system, but shift to the infarct zone following myocardial infarction, independent of sympathetic influence.
Hope et al. (1976) studied this question.
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