April 1, 1997Anesthesia & Analgesia

Ephedrine-Induced Coronary Artery Vasospasm in a Patient with Prior Cocaine Use

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Structured PICO

Population

1 42-year-old male with peripheral vascular disease, untreated glucose intolerance, 15-year smoking history, and prior cocaine use (last use 4 days prior) presenting for a right femoral-popliteal bypass procedure.

Intervention

Ephedrine 10 mg IV

Outcome

Coronary artery vasospasm and acute inferior myocardial infarctionsafety

Ephedrine and other alpha-adrenergic agonists may precipitate coronary artery vasospasm and myocardial infarction in patients with a history of chronic cocaine use, even days after last use.

Discussion

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Implication

Ephedrine may precipitate vasospasm in cocaine users; case report leaves open whether alpha-agonists warrant avoidance pending further study.

Cite This Study

Lustik et al. (1997) studied this question.

synapsesocial.com/papers/6a9175ef6d69645d56f08049 https://doi.org/10.1213/00000539-199704000-00045

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Implication

Ephedrine may precipitate vasospasm in cocaine users; case report leaves open whether alpha-agonists warrant avoidance pending further study.

Ephedrine-Induced Coronary Artery Vasospasm in a Patient with Prior Cocaine Use

Structured PICO

Discussion

Implication

Cite This Study

Ephedrine-Induced Coronary Artery Vasospasm in a Patient with Prior Cocaine Use

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider