February 1, 1994Circulation Research

Cocaine-induced microvascular spasm in Yucatan miniature swine. In vivo and in vitro evidence of spasm.

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Why the study?

Does cocaine administration reduce coronary flow reserve and induce microvascular spasm in a swine model?

Structured PICO

Does cocaine administration reduce coronary flow reserve and induce microvascular spasm in a swine model?

Population

8 Yucatan miniature swine (in vivo) and isolated coronary microvessels (in vitro)

Intervention

Successive cocaine doses (0.1, 0.5, 3, and 7 mg/kg IV) for 2 minutes at 10-minute intervals in vivo; 10(-9) to 10(-4) mol/L cocaine in vitro

Comparator

Baseline (before cocaine administration)

Outcome

Coronary flow reserve (CFR), coronary flow (CF), coronary vascular resistance (CVR), and microvessel diametersurrogate

Cocaine induces profound coronary microvascular spasm and decreases coronary flow reserve, providing a mechanism for cocaine-associated myocardial ischemia in the absence of epicardial disease.

Discussion

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Implication

Cocaine may underlie ischemia without epicardial stenosis via microvascular spasm; hypothesis-generating for human translation.

Cite This Study

Núñez et al. (1994) studied this question.

synapsesocial.com/papers/6a9175ef6d69645d56f0804d https://doi.org/10.1161/01.res.74.2.281

View Full Paper

Ask AI

Bookmark

Cocaine-induced microvascular spasm in Yucatan miniature swine. In vivo and in vitro evidence of spasm.

Structured PICO

Discussion

Implication

Cite This Study

Cocaine-induced microvascular spasm in Yucatan miniature swine. In vivo and in vitro evidence of spasm.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider