Key result
An aortic knob width of ≥36 mm predicted a renal resistive index of ≥0.7 with 71.22% sensitivity, 71.32% specificity, and an area under the curve of 0.729 (p<0.001).
Why the study?
Does aortic knob width (AKW) on chest radiography predict elevated renal resistive index (RI ≥0.7) in patients with essential hypertension?
Observational (n=268)
Single-blind
No
Does aortic knob width (AKW) on chest radiography predict elevated renal resistive index (RI ≥0.7) in patients with essential hypertension?
Effect estimate: AUC 0.729 (95% CI 0.667-0.790)
p-value: p=<0.001
Aortic knob width ≥36 mm on routine chest radiography is a significant predictor of elevated renal resistive index and subclinical renal dysfunction in patients with essential hypertension.
Aortic knob width may support noninvasive RRI assessment; leaves open its role in risk stratification pending validation.
The scientific studies that have been conducted so far highlight that renal resistive index (RI) and aortic knob width (AKW) indicate poor prognosis regarding renal and cardiovascular mortality. But the existence of a direct relationship RI and AKW is unclear. This study aims investigating the relationship between RI and the measured AKW in chest radiography of the patients with hypertensive nephropathy who do not require renal replacement therapy.This prospective study included 268 consecutive patients with essential hypertension. Patients were divided into 2 groups as RI ≥0.7 and RI <0.7. The ROC curve, sensitivity, and specificity ratios were evaluated to determine which AKW value is the best predictive one for the RI ≥0.7.The cutoff point of AKW was evaluated as ≥36 for the cases with RI ≥0.7: sensitivity was 71.22%; specificity was 71.32%; the positive predictive value (PPV) was 72.79; the negative predictive value (NPV) was 69.70, and the accuracy was 71.27. Area under the ROC curve ± standard error (AUC ± SE) = 0.729 ± 0.031 (P < .001).AKW can provide important predictive information about the subclinical renal dysfunction in hypertensive patients with RI ≥0.7. Moreover; AKW is a predictive factor for both the diagnostic and prognostic evaluation of renal pathologies.
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Sevencan et al. (2018) conducted an observational in Essential hypertension (n=268). Aortic knob width vs. Renal resistive index <0.7 was evaluated on Predictive value of aortic knob width for renal resistive index ≥0.7 (AUC 0.729, 95% CI 0.667-0.790, p=<0.001). An aortic knob width of ≥36 mm predicted a renal resistive index of ≥0.7 with 71.22% sensitivity, 71.32% specificity, and an area under the curve of 0.729 (p<0.001).
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