Key result
An aortic knob width cut-off of 41 mm on chest X-ray identified subclinical atherosclerosis in hypertensive patients with 71% sensitivity and 77% specificity (AUC 0.67, 95% CI 0.51-0.82).
Why the study?
Does aortic knob width on chest X-ray predict subclinical atherosclerosis in hypertensive patients?
Cross-Sectional (n=374)
Does aortic knob width on chest X-ray predict subclinical atherosclerosis in hypertensive patients?
Effect estimate: AUC 0.67 (95% CI 0.51-0.82)
Aortic knob width measurement on a routine chest X-ray may serve as a simple, accessible marker for predicting subclinical atherosclerosis in hypertensive patients.
OBJECTIVE: The aim of our study was to determine the usefulness of the aortic knob width (AKW) in the assessment of subclinical atherosclerosis in hypertensive patients. METHODS: In this study on diagnostic accuracy, 374 consecutive hypertensive patients with at least one cardiovascular risk factor were enrolled. AKW was measured on chest X-ray. Cardio-ankle vascular index (CAVI) was measured by VaSera-1000 CAVI instrument. The diagnostic value of AKW was assessed using ROC analysis. RESULTS: There was a significant correlation between aortic knob width and CAVI (r=0.45, p<0.001), age (0.39, p<0.001), systolic (r=0.17, p<0.001), diastolic (r=0.23, p<0.001) and mean (r=0.2, p<0.001) blood pressures. In linear regression analysis CAVI (β=0.3, 95% CI 0.33-0.98, p<0.001), age (β=0.3, 95% CI 0.09 - 0.21, p<0.001) and diastolic blood pressure β=0.2, 95% CI 0.08-1.9, p<0.001) were independently associated with AKW. It was significantly higher in patients with subclinical atherosclerosis (CAVI ≥9) than borderline (8 ≤CAVI <9) (41.4±5.5 versus 36.7±5.3 mm, p<0.001) and healthy (CAVI <8) subjects (41.4±5.5 versus 35.5±4.3 mm, p<0.001). Analysis using the ROC curve has demonstrated that aortic knob of 41 mm constitutes the cut-off value for the presence of subclinical atherosclerosis with 71% sensitivity and 77% specificity (AUC-0.67, 95% CI 0.51-0.82). CONCLUSION: Observation of aortic knob on chest X-ray in hypertensive patients may provide important predictive information of subclinical atherosclerosis.
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Korkmaz et al. (2012) conducted a cross-sectional in Hypertension (n=374). Aortic knob width measurement vs. Cardio-ankle vascular index (CAVI) was evaluated on Presence of subclinical atherosclerosis (CAVI ≥9) (AUC 0.67, 95% CI 0.51-0.82). An aortic knob width cut-off of 41 mm on chest X-ray identified subclinical atherosclerosis in hypertensive patients with 71% sensitivity and 77% specificity (AUC 0.67, 95% CI 0.51-0.82).
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