Key result
Aortic knob width measured on chest radiography independently predicted carotid intima-media thickness in patients with essential hypertension (β=0.5, P<0.001).
Why the study?
Does aortic knob width measured on chest radiography predict carotid intima-media thickness in patients with essential hypertension?
Cross-Sectional (n=126)
Does aortic knob width measured on chest radiography predict carotid intima-media thickness in patients with essential hypertension?
Effect estimate: β=0.5
p-value: p=<0.001
Aortic knob width measured on routine chest radiography independently predicts carotid intima-media thickness, offering a simple marker for subclinical atherosclerosis in hypertensive patients.
May support aortic knob width as a simple marker of subclinical atherosclerosis in hypertension; hypothesis-generating and requires prospective validation.
OBJECTIVE: The assessment of subclinical atherosclerosis is important in the evaluation of a hypertensive patient, as it provides information on the severity of the hypertension and the cardiovascular risk. The aim of this study was to determine the usefulness of the aortic knob width measured on chest radiography in the assessment of subclinical atherosclerosis in hypertensive patients. METHOD AND RESULTS: A total of 126 consecutive hypertensive patients were enrolled. In univariate analysis, there was a strong correlation between carotid intima media thickness (CIMT) and aortic knob width (r=0.62, P<0.001). In addition, there were statistically significant correlations between CIMT and age (r=0.42, P<0.001), systolic pressure (r=0.27, P=0.02), diastolic pressure (r=0.28, P<0.03), and pulse pressure (r=0.31, P<0.001). In linear regression analysis, the aortic knob width (β=0.5, P<0.001), age (β=0.02, P=0.03), and systolic pressure (β=0.03, P=0.005) were the only independent predictors of CIMT. CONCLUSION: Observation of aortic knob on chest radiograph in hypertensive patients may provide important predictive information of subclinical atherosclerosis.
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Erkan et al. (2011) conducted a cross-sectional in essential hypertension (n=126). Aortic knob width was evaluated on Carotid intima-media thickness (CIMT) (β=0.5, p=<0.001). Aortic knob width measured on chest radiography independently predicted carotid intima-media thickness in patients with essential hypertension (β=0.5, P<0.001).
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