Key result
Aortic knob width was significantly associated with metabolic syndrome and its components, demonstrating moderate discriminatory power to identify the condition in premenopausal women (AUC 0.79).
Why the study?
Is aortic knob width measured on chest radiography associated with metabolic syndrome in adults?
Cross-Sectional (n=3,705)
Single-blind
No
Is aortic knob width measured on chest radiography associated with metabolic syndrome in adults?
Effect estimate: AUC 0.74 (95% CI 0.72-0.76)
p-value: p=<0.001
Aortic knob width measured on routine chest radiography is significantly associated with metabolic syndrome and its components, suggesting potential utility as a simple surrogate marker for cardiovascular risk.
May support aortic knob measurement on chest X-rays for metabolic syndrome risk stratification; leaves open prospective validation before clinical use.
BACKGROUND: Both aortic knob width and metabolic syndrome are suggested to be related to atherosclerosis and cardiovascular diseases. However, the association between aortic knob width and metabolic syndrome is unknown. This study aimed to explore this relationship. METHODS: Participants were 3,705 Korean adults aged 18-79 years who visited the health promotion center of a general hospital. Data on chest radiography, physical measurements, medical and social history, and blood tests were collected. We defined metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria. A single reviewer measured aortic knob width on chest radiography. RESULTS: Aortic knob width was significantly correlated with age; body mass index; waist circumference; systolic and diastolic blood pressures; total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting glucose, glycated hemoglobin, insulin, and uric acid levels; and homeostatic model assessment of insulin resistance values. Aortic knob width significantly increased as the number of metabolic syndrome components increased. Moreover, metabolic syndrome component values tended to increase across the quartile groups of aortic knob width after adjusting for age, exercise, smoking status, and alcohol use. Through receiver operating characteristic curve analysis, we determined the clinically useful cutoff value for aortic knob width to be 30.47 mm in premenopausal women. CONCLUSION: Aortic knob width was found to be significantly related to metabolic syndrome and its individual components.
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Lee et al. (2018) conducted a cross-sectional in Metabolic Syndrome (n=3,705). Aortic knob width vs. Lower aortic knob width was evaluated on Discriminatory ability of aortic knob width to identify metabolic syndrome overall (AUC 0.74, 95% CI 0.72-0.76, p=<0.001). Aortic knob width was significantly associated with metabolic syndrome and its components, demonstrating moderate discriminatory power to identify the condition in premenopausal women (AUC 0.79).
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