Key result
Early-appearing myosin families (II and I) function as generalists across cell types, while more recently evolved families function as specialists limited to specific organisms or cell types.
Population
232 myosin heavy chains from 65 organisms representing the protist, plant, and animal kingdoms
Design
Other
Authors
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Does not support changes in myosin-targeted cardiac therapies; leaves open functional specialization in human disease.
Early-appearing myosin families function as generalists, whereas more recently evolved families function as specialists limited to specific organisms or cell types.
Thompson et al. (2002) studied this question. Phylogenetic analysis was evaluated on Evolutionary history and phylogenetic relationships of the myosin superfamily. Early-appearing myosin families (II and I) function as generalists across cell types, while more recently evolved families function as specialists limited to specific organisms or cell types.
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