Left atrial tear and rupture of mitral chordae tendineae can occur as fatal cardiovascular complications in patients with osteogenesis imperfecta.
May cause fatal hemopericardium in osteogenesis imperfecta; hypothesis-generating and should not yet change practice.
A 60 year old man with features of osteogenesis imperfecta presented in biventricular failure with evidence of mitral regurgitation. He responded to conventional treatment but later collapsed and died at home. Necropsy showed a haemopericardium caused by a tear in the left atrium. There was also rupture of the mitral chordae tendineae.
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Rogerson et al. (1986) studied this question.
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