Key result
Cholesterol feeding decreased vascular endothelial-dependent relaxation, with 14-week 0.5% cholesterol inducing the least dilation compared to control (-15% vs -38%, P=0.003).
Why the study?
Does cholesterol feeding impair vascular endothelial function and increase atherogenesis in New Zealand White male rabbits?
Population
17 New Zealand White male rabbits
Comparison
Cholesterol-containing diets vs Control diet (noncholesterol)
Design
Preclinical, randomized into four groups
Follow-up
10 or 14 weeks
Authors
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Highlights cumulative cholesterol effects on endothelial function in rabbits; leaves open applicability to human atherogenesis.
RCT (n=17)
randomized
Does cholesterol feeding impair vascular endothelial function and increase atherogenesis in New Zealand White male rabbits?
Absolute Event Rate: -15% vs -38%
p-value: p=0.003
Cumulative exposure to cholesterol, rather than just serum levels, drives aortic lipid lesion formation and impairs vascular endothelial relaxation in a rabbit model.
Sun et al. (2000) conducted an RCT in Vascular endothelial dysfunction and atherogenesis (n=17). Cholesterol-containing diets vs. Noncholesterol diet was evaluated on Vascular dilation at a concentration of 10−7M acetylcholine (p=0.003). Cholesterol feeding decreased vascular endothelial-dependent relaxation, with 14-week 0.5% cholesterol inducing the least dilation compared to control (-15% vs -38%, P=0.003).
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