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This review describes the fundamental dynamical mechanisms of cardiac alternans, showing how cellular-level alternans underlies tissue and ECG manifestations.
Understanding the dynamical mechanisms of cardiac alternans from cellular to organ level is important for developing effective anti-arrhythmic strategies.
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Cellular alternans mechanisms remain hypothesis-generating; leaves open translation to anti-arrhythmic strategies without prospective validation.
Cardiac alternans describes contraction of the ventricles in a strong-weak-strong-weak sequence at a constant pacing frequency. Clinically, alternans manifests as alternation of the T-wave on the ECG and predisposes individuals to arrhythmia and sudden cardiac death. In this review, we focus on the fundamental dynamical mechanisms of alternans and show how alternans at the cellular level underlies alternans in the tissue and on the ECG. A clear picture of dynamical mechanisms underlying alternans is important to allow development of effective anti-arrhythmic strategies.
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Sato et al. (2013) conducted a review in Cardiac alternans. This review describes the fundamental dynamical mechanisms of cardiac alternans, showing how cellular-level alternans underlies tissue and ECG manifestations.
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