What question did this study set out to answer?

To review and characterize the divergent functional roles of the interleukin-17 signaling pathway and neutrophils during respiratory infections caused by dimorphic fungal pathogens.

December 14, 2020Frontiers in Cellular and Infection MicrobiologyOpen Access

The Role of the Interleukin-17 Axis and Neutrophils in the Pathogenesis of Endemic and Systemic Mycoses

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Authors

JPJuan David Puerta-AriasUniversidad de Medellín SMSusana P. MejíaUniversidad de Antioquia ÁGÁngel GonzálezUniversidad de Antioquia

Discussion

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Implication

Review uncovers dual protective and pathological roles of interleukin-17 and neutrophils in systemic mycoses, highlighting pathogen-specific immune responses.

Key Points

To review and characterize the divergent functional roles of the interleukin-17 signaling pathway and neutrophils during respiratory infections caused by dimorphic fungal pathogens.
Synthesized molecular and immunological evidence across major dimorphic fungal genera, including Histoplasma, Coccidioides, Blastomyces, and Paracoccidioides.
Evaluated upstream activation of pattern recognition receptors (Dectin-1, Dectin-2, TLRs, NLRP3) and intracellular adaptor proteins (Card9, MyD88) driving Th17 and neutrophil responses.
Pattern recognition receptor engagement triggers IL-17-mediated leukocyte recruitment and proinflammatory cytokine cascades through Card9 and MyD88 signaling pathways in a pathogen-dependent manner.
Neutrophil activation, subset polarization, and neutrophil extracellular trap release mediate vital fungal clearance in some mycoses but drive severe inflammatory tissue pathology in others.

Cite This Study

Puerta-Arias et al. (2020) studied this question.

synapsesocial.com/papers/6a917d428c4797ddb5a161ec https://doi.org/10.3389/fcimb.2020.595301

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Implication

Review uncovers dual protective and pathological roles of interleukin-17 and neutrophils in systemic mycoses, highlighting pathogen-specific immune responses.

The Role of the Interleukin-17 Axis and Neutrophils in the Pathogenesis of Endemic and Systemic Mycoses

Discussion

Member takes

Implication

Key Points

Cite This Study

The Role of the Interleukin-17 Axis and Neutrophils in the Pathogenesis of Endemic and Systemic Mycoses

Discussion

Member takes

Implication

Key Points

Cite This Study

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