Key result
Rapid atrial pacing at 300/min or more in fetal lambs decreased right ventricular output from 382 to 210 mL/kg/min and induced fetal circulatory failure.
Why the study?
Does rapid atrial pacing induce fetal circulatory failure in a fetal lamb model?
Does rapid atrial pacing induce fetal circulatory failure in a fetal lamb model?
Absolute Event Rate: 210% vs 382%
In a fetal lamb model, rapid atrial pacing at rates of 300/min or more induces fetal circulatory failure, characterized by decreased right ventricular output and increased central venous pressure.
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Hypothesis-generating for fetal tachyarrhythmia effects; human translation requires prospective validation.
Shiraishi et al. (1999) studied Fetal circulatory failure (n=5). Rapid atrial pacing vs. No pacing (control) was evaluated on Right ventricular output. Rapid atrial pacing at 300/min or more in fetal lambs decreased right ventricular output from 382 to 210 mL/kg/min and induced fetal circulatory failure.
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