Key result
Direct fetal administration of adenosine via the umbilical vein instantly terminated incessant supraventricular tachycardia in a 28-week-old fetus with severe hydrops.
Why the study?
Does direct fetal administration of adenosine terminate incessant supraventricular tachycardia in a hydropic fetus?
Case Report (n=1)
Does direct fetal administration of adenosine terminate incessant supraventricular tachycardia in a hydropic fetus?
Direct fetal administration of adenosine via the umbilical vein can instantly terminate incessant supraventricular reentry tachycardia in hydropic fetuses.
Answers are grounded in this paper and cite their sources.
May offer rescue option in refractory fetal SVT with hydrops; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: Adenosine terminates supraventricular reentry tachycardia safely and effectively in the pediatric age group. CASE: The recurrence of pretreated incessant tachycardia led to severe hydrops in a 28-week-old fetus. The tachycardia was terminated instantly with direct fetal administration of adenosine via the umbilical vein. Normal heart rate and rhythm were then preserved temporarily with digoxin and flecainide. CONCLUSION: Direct fetal adenosine administration might be helpful in the treatment of fetal reentry tachycardias if the sinus rhythm achieved quickly can be preserved by long-acting antiarrhythmic drugs. Such a combined therapeutic approach might be especially advantageous in hydropic fetuses.
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Thomas Kohl (1995) conducted a case report in Incessant supraventricular tachycardia with severe hydrops (n=1). Direct fetal administration of adenosine via the umbilical vein was evaluated on Termination of tachycardia. Direct fetal administration of adenosine via the umbilical vein instantly terminated incessant supraventricular tachycardia in a 28-week-old fetus with severe hydrops.
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