Key result
Direct fetal amiodarone administration in a 26-week fetus resulted in conversion to sinus rhythm, resolution of hydrops, and normal growth until delivery at 39 weeks.
Why the study?
Fetal supraventricular tachycardia can cause fetal heart failure and intrauterine death, and its management varies across institutions and carries risks of maternal adverse events.
Does direct fetal amiodarone administration improve outcomes in a fetus with supraventricular tachycardia and hydrops fetalis?
Design
Case report
Follow-up
Until delivery at 39 weeks gestational age
Authors
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May support direct fetal amiodarone in select refractory SVT with hydrops; hypothesis-generating and requires prospective validation before wider use.
Case Report (n=1)
Does direct fetal amiodarone administration improve outcomes in a fetus with supraventricular tachycardia and hydrops fetalis?
Direct fetal amiodarone administration may be an effective option for treating fetal SVT with hydrops, leading to sinus rhythm conversion and normal fetal growth.
Adenin et al. (2023) conducted a case report in Fetal supraventricular tachycardia (SVT) with hydrops (n=1). Direct fetal amiodarone administration was evaluated on Cardioversion to sinus rhythm and resolution of fetal hydrops. Direct fetal amiodarone administration in a 26-week fetus resulted in conversion to sinus rhythm, resolution of hydrops, and normal growth until delivery at 39 weeks.
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