Key result
Muscle lactate in excised rat muscle exhibits a bi-exponential transverse relaxation with a short T2 of 33+/-5 msec and a long T2 of 230+/-10 msec, compatible with compartmentation.
Muscle lactate exhibits bi-exponential transverse relaxation, suggesting compartmentation between intra- and extracellular pools.
May affect lactate MRS interpretation; hypothesis-generating for in vivo human validation.
To elucidate the low proton nuclear magnetic resonance (NMR) visibility of muscle lactate previously demonstrated in excised rat muscle, lactate transverse relaxation was investigated in the same model using double quantum editing sequences with effective echo times ranging from 55 to 475 msec. On this time scale, muscle lactate clearly exhibits a bi-exponential transverse relaxation with a short T2 of 33+/-5 msec (mean +/- SE, n = 3) and a long T2 of 230+/-10 msec. The relative populations (84+/-4% vs. 16+/-4%, respectively) of these two lactate pools are compatible with compartmentation between intra- and extracellular muscle lactate.
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Jouvensal et al. (1999) studied this question. Double quantum editing sequences was evaluated on Lactate transverse relaxation (T2). Muscle lactate in excised rat muscle exhibits a bi-exponential transverse relaxation with a short T2 of 33+/-5 msec and a long T2 of 230+/-10 msec, compatible with compartmentation.
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