Key result
Leptin might indirectly stimulate muscle UCP3 expression, while beta(3)-adrenoceptors are crucial for the appearance of UCP1-expressing cells in white adipose tissue.
This review highlights the potential thermogenic roles of UCP3 and the influence of leptin and beta(3)-adrenoceptors on uncoupling protein expression in adipose and muscle tissues.
Leaves open therapeutic targeting of leptin or beta(3)-adrenoceptors for thermogenesis; prospective trials needed before clinical consideration.
The hypothesis that the novel uncoupling protein UCP3 is thermogenic and/or thermoregulatory is discussed. In vitro, ex vivo, and in vivo models are presented. The beta(3)-adrenoceptors are crucial for the appearance of UCP1-expressing cells in the white adipose tissue. These cells might differ from classical brown adipocytes. Besides its well-known effect on brown adipose tissue UCP1, leptin might stimulate indirectly muscle UCP3 expression.
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Jean‐Paul Giacobino (2002) conducted a review in Obesity. Leptin might indirectly stimulate muscle UCP3 expression, while beta(3)-adrenoceptors are crucial for the appearance of UCP1-expressing cells in white adipose tissue.
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