Key result
LV systolic dysfunction was uncommon during pregnancy (5.6%) and postpartum (10.2%; p=0.340), and serum selenium did not significantly correlate with indices of LV function.
Why the study?
The study aimed to determine the prevalence of LV systolic and diastolic dysfunction and its relationship with serum selenium in healthy pregnant women within a population with high PPCM prevalence.
Does serum selenium correlate with left ventricular systolic or diastolic dysfunction in apparently healthy pregnant women?
Cohort (n=108)
Yes
Does serum selenium correlate with left ventricular systolic or diastolic dysfunction in apparently healthy pregnant women?
In a population with a high prevalence of peripartum cardiomyopathy, LV dysfunction and selenium deficiency are uncommon during healthy pregnancy, and serum selenium does not correlate with LV function.
Answers are grounded in this paper and cite their sources.
LV dysfunction screening may be warranted in late pregnancy in high-PPCM regions; leaves open selenium's preventive role pending confirmation.
Background: The study aimed to determine the prevalence of left ventricular (LV) systolic and diastolic dysfunction in apparently healthy pregnant women and if there is relationship with serum selenium, in a society with high prevalence of peripartum cardiomyopathy (PPCM).Methods: This was a prospective longitudinal study carried out in 3 centres in Kano, Nigeria. 108 apparently healthy pregnant women were consecutively recruited between the 28th and 38th weeks of gestation and re-evaluated at the 6th to 8th weeks postpartum. Serum selenium was measured at enrolment during pregnancy. LV systolic dysfunction was defined as LV ejection fraction (LVEF) below 50%. Results: LV systolic dysfunction and diastolic dysfunction were found in 6 subjects (5.6%) and 20 subjects (18.5%) during pregnancy, and in 9 subjects (10.2%) (p=0.340) and 14 (15.9%) (p=0.631) after delivery, respectively. Mean LVEF was 62.2±6.9% and 60.6±8.2% (p=0.108) during pregnancy and after delivery respectively. Selenium deficiency (<70μg/L) was found in only 2.8% of subjects, and serum selenium did not significantly correlate with indices for LV systolic (LVEF) or diastolic (mitral E/e’ ratio) functions both during pregnancy and after delivery. Conclusion: LV systolic and diastolic dysfunction and selenium deficiency were uncommon during apparently healthy pregnancy and early puerperium, and serum selenium did not correlate with indices for LV function, in a population with high prevalence of PPCM.
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Karaye et al. (2020) conducted a cohort in Apparently healthy pregnancy (n=108). Pregnancy vs. Postpartum was evaluated on Left ventricular systolic dysfunction (p=0.340). LV systolic dysfunction was uncommon during pregnancy (5.6%) and postpartum (10.2%; p=0.340), and serum selenium did not significantly correlate with indices of LV function.
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