Why the study?
Does perindopril prevent reduced endothelial-mediated relaxation in a rat model of vascular calcium overload?
Population
Young rats treated with vitamin D3 plus nicotine (model of vascular calcium overload)
Comparison
Prolonged treatment with the angiotensin I… vs No perindopril treatment (implied control group)
Design
Preclinical
Follow-up
Prolonged
Authors
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Should not change practice; extends perindopril benefits to endothelial relaxation in rat vascular calcification models.
Does perindopril prevent reduced endothelial-mediated relaxation in a rat model of vascular calcium overload?
In a rat model of vascular calcium overload, perindopril prevents the reduction in endothelial-mediated vasorelaxation.
Henrion et al. (1991) studied this question.
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