Efficient Intramolecular Oxidative Amination of Olefins through Direct Dioxygen-Coupled Palladium Catalysis

Facile and efficient: a palladium-catalyzed intramolecular oxidative amination reaction [Eq. (1)] that uses molecular oxygen as a stoichiometric oxidant. These reactions require no cocatalyst for efficient reoxidation of the palladium, they operate in solvents ranging from heptane to dimethylsulfoxide, and achieve up to 250 turnovers (TO) and rates of 70 TO h−1.