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A quantitative assay for lathyrogenic agents utilizing induced fragility and extractability of collagen from bones of the chick embryo is reported. Both parameters are dosage dependent and parallel each other. The method has merits of ease, rapidity, reproducibility, and single dose requirement. Fifteen compounds consisting of 5 known lathyrogens and a number of analogues were assayed. Iproniazid phosphate had no enhancing effect on lathyrogenic activity. No correlation between dose and extractable hexosamine and tyrosine were found.
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Gross et al. (1960) studied this question.
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