Key result
Acute ischemic kidney injury in patients with myocardial infarction was associated with a significantly lower left ventricular ejection fraction (43.0% vs 57.0%, p<0.001) and a higher prevalence of multivessel coronary artery disease.
Why the study?
Acute kidney injury frequently develops in patients with myocardial infarction and is prognostically unfavorable, requiring in-depth study of cardiovascular structural and functional changes.
Observational (n=109)
No
Absolute Event Rate: 43% vs 57%
p-value: p=<0.001
In patients with STEMI, the development of acute ischemic kidney injury is associated with more severe myocardial ischemia, worse left ventricular systolic function, and more extensive multivessel coronary artery disease.
According to the epidemiological studies, in patients with myocardial infarction acute kidney injury develops in the majority of cases. This combination of pathologies is prognostically unfavorable and requires an in-depth study. The article presents the examination data of the structural and functional state of the cardiovascular system of 109 patients with acute ST-segment elevation myocardial infarction (STEMI). The studied patients were divided into two groups. The main group consisted of patients, whose myocardial infarction was complicated by the development of acute ischemic kidney injury (n = 65); the comparison group included patients with myocardial infarction and normal kidney function (n = 44). The results of electrocardiography, echocardiography and coronary angiography of the studied patients were analyzed. Patients with myocardial infarction and acute ischemic kidney injury were characterized by more pronounced ischemic changes according to electrocardiography, a more pronounced decrease in local and global contractility of the left ventricle, a larger size of the left ventricular cavity, a more frequent incidence of coronary artery multivascular lesions, a greater proportion of patients with thrombotic occlusion of the associated artery infarction and a more frequent localization of the lesion in the left anterior descending artery.
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Brankouskaya et al. (2019) conducted an observational in Acute ST-segment elevation myocardial infarction (STEMI) (n=109). Acute ischemic kidney injury vs. Normal kidney function was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.001). Acute ischemic kidney injury in patients with myocardial infarction was associated with a significantly lower left ventricular ejection fraction (43.0% vs 57.0%, p<0.001) and a higher prevalence of multivessel coronary artery disease.
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