Key result
Computerized vectorcardiography ST change vector magnitude correlated strongly with myocardium at risk estimated by scintigraphy (r = 0.84, p < 0.001) during transient coronary occlusion.
Why the study?
Does computerized vectorcardiography accurately estimate myocardium at risk compared to Tc-99m-sestamibi-SPECT during transient transmural ischemia in patients with stable angina?
Observational (n=37)
Does computerized vectorcardiography accurately estimate myocardium at risk compared to Tc-99m-sestamibi-SPECT during transient transmural ischemia in patients with stable angina?
Effect estimate: r = 0.84
p-value: p=<0.001
Computerized vectorcardiography provides a reliable estimate of myocardium at risk during transient coronary occlusion, correlating well with SPECT imaging.
May support vectorcardiography for estimating myocardium at risk in stable angina; leaves open prospective validation versus SPECT.
OBJECTIVE: To compare the myocardium at risk (MAR) as estimated by computerized vectorcardiography (cVCG) with MAR determined by Tc-99m-sestamibi-SPECT using coronary angioplasty as the model for transient transmural ischemia in humans. METHODS AND RESULTS: In 37 patients with stable angina pectoris, cVCG was recorded continuously during coronary angioplasty. The scintigraphic defect was quantified using an automated software program (CEqual). The ST vector magnitude (ST-VM) and the ST change vector magnitude (STC-VM) correlated well with MAR estimated by scintigraphy, ST-VM (r = 0.71, p < 0.001) and STC-VM (r = 0.84, p < 0.001). All patients with STC-VM <50 microV during occlusion had defects of less than 10% of the left ventricle. CONCLUSION: 1) ST-VM and STC-VM give a reasonable useful estimate of MAR size during transient coronary occlusion. 2) STC-VM <50 microV is a reliable limit to identify patients with MAR size less than 10%. 3) ST-VM does not add information to STC-VM with respect to detection of ischemia. 4) The existence of collateral vessels has great impact on both ST-vector changes and scintigraphic imaging of myocardial ischemia.
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Jensen et al. (2002) conducted an observational in Stable angina pectoris (n=37). Computerized vectorcardiography (cVCG) vs. Tc-99m-sestamibi-SPECT was evaluated on Correlation of ST change vector magnitude (STC-VM) with myocardium at risk estimated by scintigraphy (r = 0.84, p=<0.001). Computerized vectorcardiography ST change vector magnitude correlated strongly with myocardium at risk estimated by scintigraphy (r = 0.84, p < 0.001) during transient coronary occlusion.
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