The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic

As the tide of chemicals born of the Industrial Age has arisen to engulf our environment, a drastic change has come about in the nature of the most serious public health problems. Rachel Carson, Silent Spring, 1962 Worldwide rates of diabetes and other metabolic diseases have exploded over the last several decades. Globally, more than 170 million individuals currently suffer from diabetes, and this number is projected to reach a stagger-ing 366 million by 2030 (1). This scourge results in signif-icant individual morbidity and mortality while contributing to the economic fragility of healthcare systems across the globe. In the U.S. alone, annual costs associated with di-abetes are estimated to be $174 billion (2). As such, every effort must be made to understand the factors underlying this emerging metabolic disaster in order to mitigate its