Key result
5'-nor carbocyclic adenosine analogues, particularly compounds 2, 3, 5, and 8, potently inhibited measles virus replication in vitro with EC90 values ≤0.4 mg/ml and no significant cytotoxicity.
Population
CV-1 monkey kidney cells infected with measles virus (MV), including strain Chicago-1 and other strains
Design
Preclinical
Authors
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May support further antiviral development for measles; leaves open translation from in vitro activity to in vivo or clinical use.
Certain 5'-nor carbocyclic adenosine analogues demonstrate potent in vitro inhibition of measles virus replication, suggesting potential as antiviral agents.
Barnard et al. (2001) studied Measles virus infection. 5'-nor carbocyclic adenosine analogues was evaluated on Anti-measles virus activity (EC50 and EC90 values). 5'-nor carbocyclic adenosine analogues, particularly compounds 2, 3, 5, and 8, potently inhibited measles virus replication in vitro with EC90 values ≤0.4 mg/ml and no significant cytotoxicity.
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