Evidence for a pool of non‐recycling transferrin receptors in peripheral sheep reticulocytes

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Population

Peripheral sheep reticulocytes from phlebotomized animals

Design

Preclinical

Authors

Discussion

Indicates heterogeneity in reticulocyte receptor recycling; hypothesis-generating for iron trafficking, requires human validation.

Population

Peripheral sheep reticulocytes from phlebotomized animals

Intervention

Long-term incubation and removal of surface receptors with pronase

Outcome

Transferrin binding capacity and receptor recyclingsurrogate

This preclinical study demonstrates the existence of a non-recycling internal pool of transferrin receptors in sheep reticulocytes.

Adam et al. (1986) studied this question.

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